By Ferran Algaba, Isabell A. Sesterhenn (auth.), M. Pilar Laguna, Peter Albers, Carsten Bokemeyer, Jerome P. Richie (eds.)

Cancer of the Testis offers an intensive account of each element of this sickness, together with histology, danger components, analysis, scientific presentation, prognosis and remedy. also, there's a concentrate on the pertinent problems with fertility, past due results of basic treatment, follow-up after basic therapy and testicular melanoma in childhood.

With a world authorship created from a few of the key members to the sphere, this booklet brings jointly a wealthy and balanced variety of views.

A cutting-edge reference quantity on testicular melanoma, this e-book is key analyzing for urologists, scientific oncologists and radio-oncologists.

M. Pilar Laguna, MD PhD, is an affiliate Professor in Urology on the college of Amsterdam, The Netherlands.

Peter Albers, MD, is Chairman of the dep. of Urology at Dusseldorf college, Germany.

Carsten Bokemeyer, MD, is Director of Oncology and Hematology at Hubertus Wald Tumorzentrum on the college clinical middle in Hamburg, Germany.

Jerome P. Richie, MD, is the Elliot C. Cutler Professor of Urologic surgical procedure at Harvard scientific institution and leader of Urology at Brigham and Women’s sanatorium in Boston, USA.

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1). Integrated analysis of both chromosomal anomalies and expression profiling demonstrated that DMRT1 is a likely candidate gene/ protein to explain the gain of chromosome 9 (Looijenga et al. 2006). Although its mechanistic basis remains to be elucidated, it can be used as an informative diagnostic marker. Interestingly this protein is also found in the testicular seminomas of dogs (Looijenga et al. 2007b), one of the supposed animal models for human SS, and it is recommended to indeed reclassify these canine tumors as SS.

Follicles in addition to large and small aggregates of tumor cells Macroscopically, they are lobulated, often with a cystic component. Microscopically, the cells are polyhedral or round and contain abundant pale to eosinophilic cytoplasm. The nuclei are round or oval and hyperchromatic with occasional nucleoli. There may be many mitoses. 33). The follicles are usually large and may contain mucoid material. By immunohistochemistry, these and Sertoli cell tumors are positive not only for vimentin but also for cytokeratins and actin Harms 1997.

2001) reported eight children with this syndrome. All had gynecomastia and bilateral testicular lesions. 5 Granulosa Cell Tumors Two types are recognized: the adult and the juvenile. Both display the same histologic patterns as their ovarian counterparts. 6 Granulosa Cell Tumor, Adult Type Only 27 cases were reported in the literature. The patients range in age from 10 to 80 years with most in the third to sixth decades. The symptoms are usually a mass, and in 25% of patients gynecomastia (Mostofi et al.

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