By Dan Longo, Bruce A. Chabner

Updated to incorporate the latest medications and people at present in improvement, Cancer Chemotherapy and Biotherapy, 5th Edition is a finished reference at the preclinical and scientific pharmacology of anticancer brokers. equipped by means of drug type, the booklet presents the most recent details on all medications and organic agents—their mechanisms of motion, interactions with different brokers, toxicities, unwanted effects, and mechanisms of resistance. Chapters emphasize pharmacology and mechanisms of motion on the molecular and mobile degrees, by means of medical task and toxicity, either acute and not on time. The authors clarify the explanation to be used of substances in particular schedules and combos and supply guidance for dose adjustment specifically situations.

This edition's creation contains well timed info on basic concepts for drug utilization, the technology of drug discovery and improvement, fiscal and regulatory points of melanoma drug improvement, and rules of pharmacokinetics. 8 new chapters were additional and greater than twenty were considerably revised.

A significant other web site comprises the absolutely searchable textual content and a picture bank.

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Extra resources for Cancer Chemotherapy and Biotherapy: Principles and Practice (Chabner, Cancer Chemotherapy and Biotherapy)

Example text

As an alternative to continuous drug infusion, periodic bolus injections may be given to maintain reasonably constant plasma levels. As with the infusion, there is an approach to steady-state values (peaks and valleys), or the steady state can be reached immediately with the proper choice of loading dose. The most common such schedule targets the peak concentration to be twice the valley concentration. This design requires dosing once each half-time. An initial dose of twice the successive (maintenance) doses abolishes the time lag.

Phase I clinical and pharmacokinetic study of hexamethylene bisacetamide (NSC95580) administered as a five-day continuous infusion. Cancer Res 1987;47:617. 18. Arbuck SG, Douglass HO, Crom WR, et al. Etoposide pharmacokinetics in patients with normal and abnormal organ function. J Clin Oncol 1986;4:1690. 19. D'Incalci M, Rossi C, Zucchetti M, et al. Pharmacokinetics of etoposide in patients with abnormal renal and hepatic function. Cancer Res 1986;46:2566. 20. Powis G. Effect of human renal and hepatic disease on the pharmacokinetics of anticancer drugs.

Oates J, Wilkinson G. Principles of drug therapy. , eds. Harrison's principles of internal medicine, 8th ed. New York: McGraw-Hill, 1977:334–346. 37. Gibaldi M, Perrier D. Pharmacokinetics, 2nd ed. New York: Marcel Dekker, 1982. 38. McManus ME, Monks A, Collins JM, et al. Nonlinear pharmacokinetics of misonidazole and desmethylmisonidazole in the isolated perfused rat liver. J Pharmacol Exp Ther 1981;219:669. 39. Dedrick RL, Forrester DD, Cannon JN, et al. Pharmacokinetics of 1-b- D-arabinofuranosylcytosine (ara-C) deamination in several species.

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