By Enrico Agabiti Rosei, Giuseppe Mancia

This publication offers up to date info on the best way to examine early preclinical changes within the middle, the small and big arteries and the kidney utilizing the main delicate, particular and competitively priced ideas. a wide selection of ideas are mentioned, with cautious cognizance to the newest advancements. for every organ, proof is documented in regards to the occurrence of organ harm within the basic and the hypertensive inhabitants. info is supplied at the power induction of regression of organ harm through remedy, the factors for setting up major alterations and the scientific prognostic importance of regression. The guide could be worthwhile for all practitioners liable for the scientific administration of hypertensive sufferers, on condition that the evaluate of early preclinical cardiovascular and renal harm allows extra exact threat stratification at baseline and allows review of cardiovascular defense while regression of structural alterations is accomplished in the course of treatment.

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J Am Coll Cardiol. 2004;44(4):878–86. 38. Maceira AM, Mohiaddin RH. Cardiovascular magnetic resonance in systemic hypertension 2. J Cardiovasc Magn Reson. 2012;14:28. 39. Celic V, Tadic M, Suzic-Lazic J, Andric A, Majstorovic A, Ivanovic B, et al. Two- and threedimensional speckle tracking analysis of the relation between myocardial deformation and functional capacity in patients with systemic hypertension. Am J Cardiol. 2014;113(5):832–9. 40. Wang J, Khoury DS, Yue Y, Torre-Amione G, Nagueh SF.

A first meta-analysis published in 2004 [28], evaluating 10 trials with 3,443 individuals (age range from 30 to 70 years) and follow-up for 1–4 years, has shown that conventional statin treatment reduces IMT progression as compared to placebo (8 studies) and that aggressive cholesterol reduction with high-dose statin may be more effective than conventional dosages. A more recent meta-analysis [29] has examined 21 randomized controlled trials involving 6,317 individuals. 013), and subgroup analyses showed a greater decrease in mean CCA-IMT in the setting of secondary prevention versus primary prevention, in younger patients versus older patients, and in studies with a greater proportion of male patients .

45. 46. 47. 48. Modern Diagnostic Approach for the Assessment of Cardiac Damage in Hypertension 37 management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31:1281–357. Maceira AM, Mohiaddin R. Cardiovascular magnetic resonance in systemic hypertension. J Cardiovasc Magn Reson. 2012;14:28. Myerson SG, Bellenger NG, Pennell DJ. Assessment of left ventricular mass by cardiovascular magnetic resonance.

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