By Stefan Hohmann

Aquaporins summarizes the current wisdom during this increasing box of study, beginning with the structural research of water channel proteins. next chapters commence with mammalian aquaporins, studying body structure and pathophysiology, research of knock-out version animals, and the rules of aquaporin functionality. additionally lined is the distribution and rules of aquaporins in crops and the functionality of water and glycerol channels in microbial structures. Key positive factors* finished remedy of a topical study box* Authored by means of international leaders within the box* Covers structural biology and body structure* Covers assorted experimental and organic structures* Chapters on plant and microbial platforms* wide therapy of mammalian body structure and pathophysiology* Structural research excellently illustrated

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1998). An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex. J. Clin. Invest. 102, 57–66. , Heymann, J. , and Fujiyoshi, Y. (2000). Structural determinants of water permeation through aqua porin-1. Nature 407, 599–605. Nagelhus, E. , Veruki, M. , Haug, F. , and Ottersen, O. P. (1998). Aquaporin-4 water channel protein in the rat retina and optic nerve: Polarized expression in M¨uller cells and fibrous astrocytes. J. Neurosci.

Chem. 267, 22115–22121. , Matthay, M. , and Verkman, A. S. (1994). Molecular cloning of a mercurial sensitive water channel expressed in selected water-transporting tissues. J. Biol. Chem. 269, 5497–5500. Hediger, M. , Coady, J. , Ikeda, T. , and Wright, E. M. (1987). Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature 330, 379–381. Heller, K. , Lin, E. , and Wilson, T. H. (1980). Substrate specificity and transport properties of the glycerol facilitator of Escherichia coli.

Van Hoek, A. , Verkman, A. , and Mitra, A. K. (1997). Three-dimensional organization of a human water channel. Nature 387, 627–630. Cowan, C. , Bioanci, L. , and Fritzsch, B. (2000). EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron 26, 417–430. Dean, R. , Rivers, R. , Zeidel, M. , and Roberts, D. M. (1999). Purification and functional reconstitution of soybean nodulin 26. An aquaporin with glycerol transport properties. Biochemistry 38, 347–353. Deen, P.

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