By Peter R. Brinsden

This significant booklet - often called 'The Bourn corridor Textbook' - advanced from educating classes held at this prestigious medical institution - one of many birthplaces of IVF and scientific reproductive medication. The content material is complete: overlaying evaluation of the infertile couple and either laboratory and medical facets of assisted reproductive applied sciences. The emphasis all through is at the functional administration of sufferers present process assisted notion therapy. The 3rd variation is an entire replace of the sphere together with multiplied sections on more recent applied sciences equivalent to reward and ICSI. The ebook is authored principally by way of present or prior participants of the Bourne corridor employees, with extra fabric from prime foreign specialists. The Bourn corridor systems, Protocols and data Sheets - formerly released as an Appendix - at the moment are incorporated on CD-ROM for ease of version for neighborhood use.

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Additional info for A Textbook of In Vitro Fertilization and Assisted Reproduction: The Bourn Hall Guide to Clinical and Laboratory Practice

Example text

The effect of increasing age on reduction in fertility has been discussed previously in this chapter. 5%) national observational study in the UK confirm this finding (Table 3). Biological age is more important than chronological age, as older women with a good response to superovulation and satisfactory cycles which result in embryos available for transfer have very reasonable chances of conceiving. The lower pregnancy rates seen in older women seem to be due partly to a worsening response to superovulation, and, in spite of increased dosages of gonadotropins, older women generally yield fewer oocytes and have higher cycle cancelation rates.

Baltimore: Williams & Wilkins, 1989: 213–32 Rowe PJ, Comhaire FH, Hargrave TB, Mellows HJ. WHO Manual for the Standardised Investigation of the Infertile Couple. Cambridge: Cambridge University Press, 1997 Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol 1986; 67: 604–6 Conway GS, Kaltass G, Patel A, et al. Characterization of idiopathic premature ovarian failure. Fertil Steril 1996; 65: 337–41 Speroff L, Glass RH, Kase GN, eds. Clinical Gynecologic Endocrinology and Infertility, 4th edn.

0 ml or more; (2) Liquefaction time within 60 min; (3) Sperm concentration ≥ 20 × 106 spermatozoa/ml; (4) Total sperm count ≥ 40 × 106 spermatozoa per ejaculate; (5) Motility ≥ 50% with forward progression, or ≥ 25% with rapid linear progression, within 60 min of ejaculation; (6) Morphology ≥ 30% with normal forms; (7) Vitality 75% or more live; (8) White blood cells ≤ 1 × 106/ml. The grading of sperm activity on an arbitrary scale of 0–4 is useful for comparing samples from the same man; problems tend to arise with fertilization should the score be less than 2.

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